|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:activatedBy
|
nerve growth factor binding
|
|
gptkbp:alternativeName
|
gptkb:NTRK1
gptkb:tropomyosin_receptor_kinase_A
|
|
gptkbp:associatedWith
|
gptkb:neuroblastoma
gptkb:cancer
gptkb:congenital_insensitivity_to_pain_with_anhidrosis
thyroid carcinoma
pain insensitivity syndromes
|
|
gptkbp:binds
|
gptkb:nerve_growth_factor
|
|
gptkbp:biologicalProcess
|
receptor tyrosine kinase activity
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:downstreamOf
|
gptkb:PLCĪ³_pathway
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:encodedBy
|
gptkb:NTRK1_gene
|
|
gptkbp:expressedIn
|
gptkb:nervous_system
immune system
|
|
gptkbp:formsComplexWith
|
gptkb:NGF
gptkb:p75NTR
|
|
gptkbp:function
|
neurotrophin receptor
|
|
gptkbp:HGNC_ID
|
8031
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TrkA receptor
|
|
gptkbp:involvedIn
|
cell signaling
neuronal differentiation
neuronal survival
|
|
gptkbp:locatedIn
|
gptkb:cell_membrane
|
|
gptkbp:locatedOnChromosome
|
1q23.1
|
|
gptkbp:memberOf
|
gptkb:Trk_receptor_family
|
|
gptkbp:mutationAssociatedWith
|
neurological disorders
|
|
gptkbp:OMIM
|
191315
|
|
gptkbp:phosphorylates
|
itself (autophosphorylation)
|
|
gptkbp:regulates
|
gptkb:synaptic_plasticity
neurite outgrowth
apoptosis inhibition
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:structure
|
transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
|
|
gptkbp:target
|
gptkb:entrectinib
gptkb:larotrectinib
cancer therapeutics
tropomyosin receptor kinase inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P04629
|
|
gptkbp:bfsParent
|
gptkb:NGFB
gptkb:NTRK1_gene
gptkb:p75_neurotrophin_receptor
|
|
gptkbp:bfsLayer
|
7
|