|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:TRK
gptkb:MTC
gptkb:TRKA
gptkb:p140-TrkA
|
|
gptkbp:associatedWith
|
gptkb:papillary_thyroid_carcinoma
gptkb:congenital_insensitivity_to_pain_with_anhidrosis
gptkb:medullary_thyroid_carcinoma
|
|
gptkbp:biologicalProcess
|
cell survival
ATP binding
protein tyrosine kinase activity
axon guidance
neuron differentiation
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
integral component of membrane
|
|
gptkbp:discoveredBy
|
gptkb:Mariano_Barbacid
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:encodes
|
gptkb:TrkA_protein
|
|
gptkbp:Entrez_Gene_ID
|
4914
ENSG00000198400
|
|
gptkbp:fullName
|
gptkb:Neurotrophic_tyrosine_kinase_receptor_type_1
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
gptkb:nerve_growth_factor_receptor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:NTRK1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NTRK1 (human)
|
|
gptkbp:inhibitedBy
|
gptkb:crizotinib
gptkb:entrectinib
gptkb:larotrectinib
|
|
gptkbp:length
|
796
|
|
gptkbp:ligand
|
gptkb:nerve_growth_factor_(NGF)
|
|
gptkbp:locatedOnChromosome
|
1
1q23.1
|
|
gptkbp:molecularWeight
|
87 kDa
|
|
gptkbp:mutationAssociatedWith
|
Fusions with TPM3, TPR, LMNA, and others in cancer
|
|
gptkbp:OMIM
|
191315
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Ntrk1_(mouse)
Ntrk1 (rat)
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:Neurotrophin_signaling_pathway
|
|
gptkbp:PDB
|
4AOJ
4GT5
6PL2
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:RefSeq
|
gptkb:NM_002529
NP_002520
|
|
gptkbp:significance
|
target for cancer therapy
|
|
gptkbp:UniProtID
|
gptkb:P04629
|
|
gptkbp:bfsParent
|
gptkb:Ntrk1
|
|
gptkbp:bfsLayer
|
8
|