NRAS proto-oncogene, GTPase

URI: https://gptkb.org/entity/NRAS_proto-oncogene,_GTPase
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:gene
gptkbp:alias gptkb:NRAS
gptkb:Neuroblastoma_RAS_viral_oncogene_homolog
gptkbp:associatedWith gptkb:cancer
gptkb:acute_myeloid_leukemia
colorectal cancer
melanoma
thyroid carcinoma
gptkbp:discoveredIn 1983
gptkbp:encodes gptkb:NRAS_protein
gptkbp:Entrez_Gene_ID 4893
gptkbp:expressedIn various tissues
gptkbp:function signal transduction
GTPase activity
gptkbp:geneType tumor suppressor
gptkbp:HGNC_ID 7989
https://www.w3.org/2000/01/rdf-schema#label NRAS proto-oncogene, GTPase
gptkbp:interactsWith gptkb:BRAF
gptkb:GRB2
gptkb:PIK3CA
gptkb:RAF1
gptkb:SOS1
gptkbp:involvedIn gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
gptkbp:length 189 amino acids
gptkbp:locatedOnChromosome 1p13.2
chromosome 1
gptkbp:memberOf gptkb:RAS_gene_family
gptkbp:molecularWeight 21 kDa
gptkbp:mutationAssociatedWith germline mutation
somatic mutation
codon 12
codon 13
codon 61
oncogenic transformation
uncontrolled cell growth
gptkbp:OMIM 164790
gptkbp:orthologInMouse gptkb:Nras
gptkbp:postTranslationalModification farnesylation
palmitoylation
gptkbp:referenceGenome gptkb:GRCh38
gptkbp:regulates apoptosis
cell differentiation
cell proliferation
gptkbp:subcellularLocation gptkb:cytoplasm
gptkb:plasma_membrane
gptkbp:UniProtID gptkb:P01111
gptkbp:bfsParent gptkb:NRAS
gptkbp:bfsLayer 5