NRAS proto-oncogene, GTPase

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:gene
gptkbp:alias	gptkb:NRAS gptkb:Neuroblastoma_RAS_viral_oncogene_homolog
gptkbp:associatedWith	gptkb:cancer gptkb:acute_myeloid_leukemia gptkb:thyroid_carcinoma gptkb:melanoma colorectal cancer
gptkbp:discoveredIn	1983
gptkbp:encodes	gptkb:NRAS_protein
gptkbp:Entrez_Gene_ID	4893
gptkbp:expressedIn	various tissues
gptkbp:function	signal transduction GTPase activity
gptkbp:geneType	gptkb:tumor_suppressor
gptkbp:HGNC_ID	7989
gptkbp:interactsWith	gptkb:BRAF gptkb:GRB2 gptkb:PIK3CA gptkb:RAF1 gptkb:SOS1
gptkbp:involvedIn	gptkb:MAPK/ERK_pathway gptkb:PI3K/AKT_pathway
gptkbp:length	189 amino acids
gptkbp:locatedOnChromosome	1p13.2 chromosome 1
gptkbp:memberOf	gptkb:RAS_gene_family
gptkbp:molecularWeight	21 kDa
gptkbp:mutationAssociatedWith	germline mutation somatic mutation codon 12 codon 13 codon 61 oncogenic transformation uncontrolled cell growth
gptkbp:OMIM	164790
gptkbp:orthologInMouse	gptkb:Nras
gptkbp:postTranslationalModification	farnesylation palmitoylation
gptkbp:referenceGenome	gptkb:GRCh38
gptkbp:regulates	apoptosis cell differentiation cell proliferation
gptkbp:subcellularLocation	gptkb:cytoplasm gptkb:plasma_membrane
gptkbp:UniProtID	gptkb:P01111
gptkbp:bfsParent	gptkb:NRAS
gptkbp:bfsLayer	5
https://www.w3.org/2000/01/rdf-schema#label	NRAS proto-oncogene, GTPase