|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:NRAS_proto-oncogene
gptkb:Neuroblastoma_RAS_oncogene
gptkb:transforming_protein_p21
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:acute_myeloid_leukemia
melanoma
thyroid carcinoma
|
|
gptkbp:discoveredIn
|
1983
|
|
gptkbp:encodes
|
gptkb:NRAS_protein
|
|
gptkbp:Entrez_Gene_ID
|
4893
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
gptkbp:fullName
|
gptkb:neuroblastoma_RAS_viral_oncogene_homolog
|
|
gptkbp:function
|
guanine nucleotide exchange factor
signal transduction
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
7989
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Nras
|
|
gptkbp:locatedOnChromosome
|
1p13.2
chromosome 1
|
|
gptkbp:memberOf
|
gptkb:RAS_gene_family
|
|
gptkbp:mutationAssociatedWith
|
drug resistance
germline mutation
somatic mutation
codon 12
codon 13
codon 61
oncogenic transformation
|
|
gptkbp:OMIM
|
164790
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
|
|
gptkbp:pathway
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:proteinFamily
|
small molecule
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:relatedTo
|
gptkb:HRAS
gptkb:KRAS
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:symbol
|
gptkb:NRAS
|
|
gptkbp:target
|
gptkb:MEK_inhibitors
farnesyltransferase inhibitors
anticancer drugs
|
|
gptkbp:UniProtID
|
gptkb:P01111
|
|
gptkbp:bfsParent
|
gptkb:NRAS
|
|
gptkbp:bfsLayer
|
5
|