|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:ABCC1
gptkb:Canalicular_multispecific_organic_anion_transporter
gptkb:Multidrug_resistance_protein_1
|
|
gptkbp:associatedWith
|
cancer drug resistance
|
|
gptkbp:discoveredBy
|
Cole SP et al.
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:encodes
|
gptkb:MRP1_protein
|
|
gptkbp:Entrez_Gene_ID
|
4363
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:kidney
gptkb:placenta
gptkb:testis
gptkb:blood-brain_barrier
liver
|
|
gptkbp:fullName
|
gptkb:Multidrug_resistance-associated_protein_1
|
|
gptkbp:function
|
transports organic anions
confers multidrug resistance
exports glutathione conjugates
|
|
gptkbp:gene
|
gptkb:ABCC1
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:54
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MRP1 (ABCC1)
|
|
gptkbp:inhibitedBy
|
gptkb:MK-571
gptkb:probenecid
gptkb:verapamil
indomethacin
|
|
gptkbp:locatedOnChromosome
|
gptkb:16q12.1
|
|
gptkbp:memberOf
|
gptkb:ABCC_subfamily
gptkb:ATP-binding_cassette_transporter_family
|
|
gptkbp:mutationAssociatedWith
|
multidrug resistance in cancer
hereditary non-syndromic sensorineural deafness
|
|
gptkbp:OMIM
|
158343
|
|
gptkbp:orthologInMouse
|
gptkb:Abcc1
|
|
gptkbp:orthologInZebrafish
|
abcc1a
|
|
gptkbp:relatedTo
|
cystic fibrosis transmembrane conductance regulator (CFTR)
P-glycoprotein (ABCB1)
|
|
gptkbp:structure
|
gptkb:cell_membrane
contains multiple transmembrane domains
contains two ATP-binding domains
|
|
gptkbp:transportation
|
gptkb:doxorubicin
gptkb:leukotriene_C4
gptkb:methotrexate
gptkb:vincristine
antineoplastic agent
antiretroviral drugs
glutathione conjugates
|
|
gptkbp:UniProtID
|
P33527
|
|
gptkbp:bfsParent
|
gptkb:MK-571
|
|
gptkbp:bfsLayer
|
7
|