|
gptkbp:instanceOf
|
gptkb:anatomical_structure
biological barrier
|
|
gptkbp:associatedWith
|
neurological diseases
|
|
gptkbp:composedOf
|
endothelial cells
pericytes
astrocyte end-feet
|
|
gptkbp:discoveredBy
|
gptkb:Max_Lewandowsky
|
|
gptkbp:discoveredIn
|
1900
|
|
gptkbp:function
|
protects brain from pathogens
regulates passage of substances from blood to brain
|
|
gptkbp:hasPart
|
basement membrane
perivascular macrophages
tight junctions
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
blood-brain barrier
|
|
gptkbp:impermeableTo
|
large molecules
many drugs
most pathogens
|
|
gptkbp:interruptedBy
|
gptkb:trauma
infection
hypertension
inflammation
|
|
gptkbp:locatedIn
|
central nervous system
|
|
gptkbp:permeableTo
|
gptkb:water
oxygen
carbon dioxide
lipid-soluble molecules
|
|
gptkbp:prevention
|
immune cell infiltration
toxins from entering brain
|
|
gptkbp:regulates
|
ion homeostasis in brain
nutrient transport to brain
waste removal from brain
|
|
gptkbp:relatedTo
|
gptkb:blood-cerebrospinal_fluid_barrier
gptkb:neurovascular_unit
|
|
gptkbp:significance
|
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
gptkb:HIV_encephalitis
meningitis
stroke
multiple sclerosis
brain tumors
drug delivery to brain
|
|
gptkbp:studiedIn
|
gptkb:pharmacy
neurology
neuroscience
pathology
|
|
gptkbp:bfsParent
|
gptkb:GLUT1_transporter
gptkb:Stanley_I._Rapoport
gptkb:MDR1
gptkb:MDR1_gene
gptkb:glucose_transporter_1_(GLUT1)
gptkb:Multidrug_resistance_protein_1
gptkb:Morphine-6-glucuronide
gptkb:PV1
gptkb:phaclofen
gptkb:SLC2A1
gptkb:bilastine
|
|
gptkbp:bfsLayer
|
7
|