Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:ABCC1
gptkb:Multidrug_resistance-associated_protein_1 |
| gptkbp:associatedWith |
multidrug resistance in cancer
|
| gptkbp:discoveredIn |
1992
|
| gptkbp:encodedBy |
gptkb:ABCC1_gene
|
| gptkbp:foundIn |
gptkb:human
other mammals |
| gptkbp:function |
transmembrane transporter
exports drugs and xenobiotics exports organic anions |
| https://www.w3.org/2000/01/rdf-schema#label |
MRP1 protein
|
| gptkbp:inhibitedBy |
gptkb:MK-571
gptkb:probenecid |
| gptkbp:locatedIn |
gptkb:cell_membrane
|
| gptkbp:locatedOnChromosome |
16p13.1
|
| gptkbp:memberOf |
gptkb:ABCC_subfamily
gptkb:ATP-binding_cassette_transporter_family |
| gptkbp:relatedTo |
toxicology
drug resistance pharmacokinetics |
| gptkbp:structure |
contains multiple transmembrane domains
contains two nucleotide-binding domains |
| gptkbp:substrate |
gptkb:leukotriene_C4
antibiotics antiviral drugs antineoplastic agents glutathione conjugates |
| gptkbp:bfsParent |
gptkb:ABCC1_gene
|
| gptkbp:bfsLayer |
7
|