Multidrug resistance protein 1

URI: https://gptkb.org/entity/Multidrug_resistance_protein_1
GPTKB entity
Statements (47)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:MDR1
gptkb:P-glycoprotein
gptkbp:associatedWith multidrug resistance in cancer
gptkbp:discoveredBy gptkb:Victor_Ling
gptkbp:discoveredIn 1976
gptkbp:encodedBy gptkb:ABCB1_gene
gptkbp:Entrez_Gene_ID 5243
ENSG00000085563
gptkbp:expressedIn gptkb:kidney
gptkb:placenta
gptkb:blood-brain_barrier
liver
intestine
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function ATP-dependent drug efflux pump
transports xenobiotics out of cells
gptkbp:HGNC_ID HGNC:40
https://www.w3.org/2000/01/rdf-schema#label Multidrug resistance protein 1
gptkbp:inhibitedBy gptkb:tariquidar
gptkb:verapamil
cyclosporin A
gptkbp:locatedOnChromosome 7q21.12
gptkbp:location gptkb:cell_membrane
gptkbp:memberOf gptkb:ATP-binding_cassette_transporter_family
gptkbp:molecularWeight ~170 kDa
gptkbp:OMIM 171050
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:PDB 6QEX
gptkbp:RefSeq NM_000927
gptkbp:role pharmacokinetics
drug distribution
drug absorption
drug excretion
protection of tissues from toxins
gptkbp:significance chemotherapy resistance
drug-drug interactions
gptkbp:structure transmembrane glycoprotein
gptkbp:substrate antibiotics
anticancer drugs
immunosuppressants
steroids
HIV protease inhibitors
gptkbp:UniProtID P08183
gptkbp:bfsParent gptkb:MRP1
gptkbp:bfsLayer 6