Multidrug resistance-associated protein 1

URI: https://gptkb.org/entity/Multidrug_resistance-associated_protein_1
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:ABCC1
gptkb:MRP1
gptkbp:associatedWith multidrug resistance in cancer
gptkbp:discoveredIn 1992
gptkbp:encodedBy gptkb:ABCC1_gene
gptkbp:Entrez_Gene_ID 4363
gptkbp:expressedIn gptkb:cancer
gptkb:kidney
gptkb:placenta
gptkb:testis
liver
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function exports drugs from cells
transports organic anions
https://www.w3.org/2000/01/rdf-schema#label Multidrug resistance-associated protein 1
gptkbp:inhibitedBy gptkb:MK-571
gptkbp:locatedOnChromosome 16p13.1
gptkbp:location gptkb:plasma_membrane
gptkbp:memberOf gptkb:ATP-binding_cassette_transporter_family
gptkbp:OMIM 173080
gptkbp:role detoxification
protection against xenobiotics
chemoresistance
gptkbp:structure contains multiple transmembrane domains
contains two ATP-binding domains
gptkbp:substrate gptkb:leukotriene_C4
antineoplastic agents
glutathione conjugates
gptkbp:UniProtID P33527
gptkbp:bfsParent gptkb:ABCC1
gptkb:MRP1
gptkbp:bfsLayer 6