Statements (54)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:pharmaceuticals
|
| gptkbp:administered_by |
oral tablet
|
| gptkbp:approves |
gptkb:2015
gptkb:FDA |
| gptkbp:atccode |
L01 XE30
|
| gptkbp:breastfeeding_category |
not recommended
|
| gptkbp:can_be_combined_with |
gptkb:vemurafenib
|
| gptkbp:casnumber |
934660-93-2
|
| gptkbp:category |
Category D
|
| gptkbp:chemical_formula |
C19 H19 Cl N6 O2 S
|
| gptkbp:clinical_trial |
Phase III
ongoing studies for other cancers |
| gptkbp:clinical_use |
in combination with vemurafenib
|
| gptkbp:contraindication |
severe liver impairment
hypersensitivity to cobimetinib |
| gptkbp:developed_by |
gptkb:Genentech
|
| gptkbp:dissolved |
soluble in DMSO
|
| gptkbp:drug_interactions |
CYP3 A4 inducers
CYP3 A4 inhibitors |
| gptkbp:excretion |
urine
|
| gptkbp:financials |
DB09063
|
| https://www.w3.org/2000/01/rdf-schema#label |
cobimetinib
|
| gptkbp:indication |
BRAF V600 E or V600 K mutation-positive melanoma
|
| gptkbp:invention |
patented until 2026
|
| gptkbp:is_monitored_by |
liver function tests
complete blood count |
| gptkbp:lifespan |
approximately 50 hours
|
| gptkbp:market_position |
available
|
| gptkbp:marketed_as |
gptkb:Cotellic
|
| gptkbp:mechanism_of_action |
MEK inhibitor
|
| gptkbp:metabolism |
liver
|
| gptkbp:monitors |
3 D1 B1 F1 F1 B
|
| gptkbp:packaging |
bottles of 30 tablets
|
| gptkbp:patient_population |
adults with advanced melanoma
|
| gptkbp:pharmacokinetics |
inhibits MAPK pathway
oral bioavailability approximately 50% |
| gptkbp:price |
varies by region and insurance
|
| gptkbp:research_focus |
combination therapies
|
| gptkbp:route_of_administration |
oral
|
| gptkbp:safety_measures |
risk of thromboembolic events
risk of serious skin reactions risk of cardiomyopathy risk of ocular toxicity |
| gptkbp:side_effect |
fatigue
nausea diarrhea rash elevated liver enzymes |
| gptkbp:storage |
store at room temperature
|
| gptkbp:targets |
MEK1 and MEK2
|
| gptkbp:type_of_care |
important for treatment efficacy
|
| gptkbp:used_for |
treatment of melanoma
|
| gptkbp:bfsParent |
gptkb:Cotellic
|
| gptkbp:bfsLayer |
6
|