|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:BCL2L3
gptkb:MCL-1
EAT
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:encodedBy
|
gptkb:MCL1_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000143384
4170
|
|
gptkbp:firstDescribed
|
1993
|
|
gptkbp:fullName
|
gptkb:Myeloid_cell_leukemia_1
|
|
gptkbp:function
|
anti-apoptotic protein
|
|
gptkbp:gene
|
gptkb:MCL1
|
|
gptkbp:HGNC_ID
|
6943
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MCL1
|
|
gptkbp:inhibitedBy
|
apoptosis
|
|
gptkbp:interactsWith
|
gptkb:BAX
gptkb:NOXA
gptkb:PUMA
gptkb:BAK1
gptkb:BCL2L11
|
|
gptkbp:involves
|
gptkb:cancer
|
|
gptkbp:locatedOnChromosome
|
1q21
|
|
gptkbp:location
|
mitochondrial outer membrane
|
|
gptkbp:member
|
gptkb:Bcl-2_family
|
|
gptkbp:OMIM
|
159552
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:overexpressedIn
|
chemoresistance
|
|
gptkbp:phosphorylates
|
gptkb:Ser159
gptkb:Thr163
|
|
gptkbp:regulates
|
regulated by ubiquitin-proteasome pathway
transcriptionally regulated by STAT3
|
|
gptkbp:target
|
gptkb:BH3_mimetics
|
|
gptkbp:therapeutic_target_in
|
gptkb:acute_myeloid_leukemia
multiple myeloma
solid tumors
|
|
gptkbp:UniProtID
|
gptkb:Q07820
|
|
gptkbp:bfsParent
|
gptkb:BAX
|
|
gptkbp:bfsLayer
|
6
|