|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:MCL1
gptkb:BCL2L3
gptkb:MCL-1
EAT
|
|
gptkbp:encodedBy
|
gptkb:MCL1_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000143384
4170
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
regulation of apoptosis
anti-apoptotic protein
|
|
gptkbp:HGNC_ID
|
6943
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Myeloid cell leukemia 1
|
|
gptkbp:interactsWith
|
gptkb:BAX
gptkb:NOXA
gptkb:BAK1
BIM
|
|
gptkbp:involvedIn
|
hematopoiesis
cancer cell survival
|
|
gptkbp:locatedOnChromosome
|
chromosome 1
|
|
gptkbp:memberOf
|
gptkb:Bcl-2_family
|
|
gptkbp:mutationAssociatedWith
|
leukemia
multiple myeloma
|
|
gptkbp:OMIM
|
159552
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:overexpressedIn
|
various cancers
|
|
gptkbp:PDB
|
2NL9
5FDO
6QFM
|
|
gptkbp:regulates
|
regulated by phosphorylation
cell death
mitochondrial outer membrane permeabilization
regulated by ubiquitination
transcriptionally regulated by STAT3
|
|
gptkbp:structure
|
contains BH1, BH2, and BH3 domains
|
|
gptkbp:subcellularLocation
|
mitochondrial membrane
|
|
gptkbp:target
|
anticancer drugs
|
|
gptkbp:UniProtID
|
gptkb:Q07820
|
|
gptkbp:bfsParent
|
gptkb:MCL1
|
|
gptkbp:bfsLayer
|
7
|