Statements (31)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:drug
|
| gptkbp:administeredBy |
oral
intravenous |
| gptkbp:approvedBy |
gptkb:acute_myeloid_leukemia
chronic lymphocytic leukemia |
| gptkbp:clinicalTrialPhase |
gptkb:Phase_I
Phase II |
| gptkbp:developedBy |
gptkb:AbbVie
gptkb:Genentech |
| gptkbp:discoveredIn |
early 2000s
|
| gptkbp:example |
gptkb:venetoclax
navitoclax S63845 obatoclax |
| https://www.w3.org/2000/01/rdf-schema#label |
BH3 mimetics
|
| gptkbp:inducedBy |
apoptosis
|
| gptkbp:mechanismOfAction |
inhibit BCL-2 family proteins
|
| gptkbp:namedAfter |
BH3 domain
|
| gptkbp:relatedTo |
apoptosis pathway
intrinsic apoptosis |
| gptkbp:sideEffect |
gptkb:tumor_lysis_syndrome
neutropenia thrombocytopenia |
| gptkbp:target |
gptkb:BCL-XL
gptkb:MCL-1 BCL-2 |
| gptkbp:usedFor |
gptkb:cancer
|
| gptkbp:bfsParent |
gptkb:Bcl-2_family_proteins
gptkb:MCL1 gptkb:BCL2_family_proteins |
| gptkbp:bfsLayer |
7
|