Statements (34)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:composedOf |
gptkb:Bcl-2_protein
Bak protein Bcl-xL protein Bad protein Bax protein Bid protein Bim protein Mcl-1 protein |
| gptkbp:contains |
anti-apoptotic proteins
pro-apoptotic proteins BH3-only proteins |
| gptkbp:discoveredIn |
1990s
|
| gptkbp:domain |
BH1 domain
BH2 domain BH3 domain BH4 domain |
| gptkbp:enemyOf |
pro-apoptotic Bcl-2 family members
|
| gptkbp:foundIn |
animals
|
| gptkbp:function |
regulation of apoptosis
|
| https://www.w3.org/2000/01/rdf-schema#label |
Bcl-2 family
|
| gptkbp:involvedIn |
gptkb:cancer
cell death mitochondrial outer membrane permeabilization |
| gptkbp:location |
outer mitochondrial membrane
|
| gptkbp:namedAfter |
gptkb:B-cell_lymphoma_2
|
| gptkbp:proteinFamily |
BCL2 gene family
|
| gptkbp:regulates |
caspase activation
cytochrome c release |
| gptkbp:target |
gptkb:BH3_mimetics
anticancer drugs |
| gptkbp:bfsParent |
gptkb:MCL1
gptkb:BCL2 |
| gptkbp:bfsLayer |
7
|