|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:BCL2L3
EAT
MCL1-ES
MCL1/BCL2L3
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
apoptosis regulation
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodes
|
Mcl-1 protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000143384
4170
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
anti-apoptotic protein
|
|
gptkbp:HGNC_ID
|
6943
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MCL1 gene
|
|
gptkbp:interactsWith
|
gptkb:BAX
gptkb:NOXA
gptkb:PUMA
gptkb:BAK
BIM
BCL-2
|
|
gptkbp:length
|
350 amino acids
|
|
gptkbp:locatedOnChromosome
|
1q21
|
|
gptkbp:memberOf
|
BCL-2 family
|
|
gptkbp:mutationAssociatedWith
|
implicated in cancer
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:overexpressedIn
|
linked to chemoresistance
|
|
gptkbp:product
|
gptkb:Mcl-1
|
|
gptkbp:protein_function
|
inhibits apoptosis
|
|
gptkbp:protein_localization
|
gptkb:nucleus
gptkb:cytoplasm
mitochondria
|
|
gptkbp:proteinFamily
|
BH1, BH2, BH3 domains
|
|
gptkbp:regulates
|
apoptosis
cell survival
phosphorylation
transcription factors
ubiquitination
microRNAs
proteasomal degradation
transcriptional and post-translational
|
|
gptkbp:significance
|
target for cancer therapy
|
|
gptkbp:target
|
gptkb:siRNA
antisense oligonucleotides
small molecule inhibitors
|
|
gptkbp:UniProtID
|
gptkb:Q07820
|
|
gptkbp:bfsParent
|
gptkb:MCL1
|
|
gptkbp:bfsLayer
|
7
|