MAPK (Mitogen-activated protein kinase)

URI: https://gptkb.org/entity/MAPK_(Mitogen-activated_protein_kinase)
GPTKB entity
Statements (41)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:activatedBy phosphorylation
MAPKK (MAP kinase kinase)
gptkbp:alternativeName gptkb:Mitogen-activated_protein_kinase
MAP kinase
gptkbp:discoveredBy gptkb:Edwin_G._Krebs
gptkb:Edmond_H._Fischer
gptkbp:EC_number 2.7.11.24
gptkbp:foundIn eukaryotes
gptkbp:function phosphorylation of target proteins
gptkbp:gene gptkb:MAPK1
gptkb:MAPK3
gptkb:MAPK14
gptkb:MAPK8
https://www.w3.org/2000/01/rdf-schema#label MAPK (Mitogen-activated protein kinase)
gptkbp:includes gptkb:ERK_(extracellular_signal-regulated_kinase)
gptkb:JNK_(c-Jun_N-terminal_kinase)
gptkb:p38_MAPK
gptkbp:inhibitedBy MAPK inhibitors
gptkbp:involvedIn signal transduction
cellular response to extracellular stimuli
gptkbp:involves gptkb:cancer
gptkb:diabetes
neurodegenerative diseases
cardiovascular diseases
inflammatory diseases
gptkbp:memberOf gptkb:protein_kinase_superfamily
serine/threonine-specific protein kinases
gptkbp:regulates apoptosis
cell differentiation
cell proliferation
cell survival
gene expression
gptkbp:relatedTo gptkb:MAPK/ERK_pathway
gptkb:MAPK_signaling_pathway
gptkbp:substrate transcription factors
cytoskeletal proteins
other kinases
gptkbp:bfsParent gptkb:CMGC
gptkbp:bfsLayer 7