ERK (extracellular signal-regulated kinase)

URI: https://gptkb.org/entity/ERK_(extracellular_signal-regulated_kinase)
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:activatedBy gptkb:MEK1
gptkb:MEK2
phosphorylation
gptkbp:alternativeName gptkb:ERK1
gptkb:ERK2
MAPK (mitogen-activated protein kinase)
gptkbp:biologicalProcess serine/threonine kinase activity
gptkbp:discoveredIn 1991
gptkbp:encodedBy gptkb:MAPK1_gene
gptkb:MAPK3_gene
gptkbp:foundIn eukaryotic cells
gptkbp:function phosphorylates target proteins
https://www.w3.org/2000/01/rdf-schema#label ERK (extracellular signal-regulated kinase)
gptkbp:inhibitedBy gptkb:PD98059
gptkb:U0126
gptkbp:involvedIn cell differentiation
cell proliferation
cell survival
signal transduction
cell cycle regulation
gptkbp:memberOf gptkb:MAP_kinase_family
gptkbp:regulates apoptosis
gene expression
metabolism
gptkbp:subcellularLocation gptkb:nucleus
gptkb:cytoplasm
gptkbp:bfsParent gptkb:Mitogen-activated_protein_kinases_(MAPKs)
gptkb:RTK-RAS-RAF-MEK-ERK_pathway
gptkb:Mitogen-activated_protein_kinase_pathway
gptkb:Raf/MEK/ERK_cascade
gptkbp:bfsLayer 7