Mitogen-activated protein kinase

URI: https://gptkb.org/entity/Mitogen-activated_protein_kinase
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:MAPK
gptkbp:activatedBy gptkb:MAP_kinase_kinase_(MAP2K)
gptkbp:discoveredIn 1990s
gptkbp:enzymeClassification gptkb:EC_2.7.11.24
gptkbp:example gptkb:ERK1
gptkb:ERK2
gptkb:JNK
gptkb:p38_MAPK
gptkbp:family serine/threonine-specific protein kinases
gptkbp:foundIn eukaryotes
gptkbp:function phosphorylates target proteins
gptkbp:GO_term GO:0000165
https://www.w3.org/2000/01/rdf-schema#label Mitogen-activated protein kinase
gptkbp:inhibitedBy gptkb:MAPK_phosphatases
gptkbp:involvedIn apoptosis
cell differentiation
signal transduction
cell division
cell growth
regulation of gene expression
cellular response to extracellular stimuli
gptkbp:mutationAssociatedWith gptkb:cancer
developmental disorders
gptkbp:orthologIn gptkb:yeast
insects
mammals
plants
gptkbp:phosphorylates gptkb:tyrosine
serine
threonine
gptkbp:regulates transcription factors
cytoskeletal proteins
other kinases
gptkbp:relatedTo gptkb:MAPK/ERK_pathway
gptkb:MAPK/JNK_pathway
gptkb:MAPK/p38_pathway
gptkbp:reviewedBy gptkb:Nature_Reviews_Molecular_Cell_Biology
gptkb:Cell_Signalling
gptkbp:structure bilobed kinase domain
gptkbp:studiedIn cancer research
developmental biology
neurobiology
inflammation
gptkbp:substrate MAP kinase-activated protein kinase
gptkbp:superfamily gptkb:protein_kinase_superfamily
gptkbp:target therapeutic drugs
gptkbp:bfsParent gptkb:MAP_kinase
gptkbp:bfsLayer 6