|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:MKK6
gptkb:MEK6
gptkb:PRKMK6
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:encodes
|
gptkb:Mitogen-activated_protein_kinase_kinase_6
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000108984
5608
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
MAP kinase kinase activity
|
|
gptkbp:HGNC_ID
|
6847
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAP2K6 gene
|
|
gptkbp:involvedIn
|
apoptosis
inflammatory response
cellular response to stress
p38 MAPK signaling pathway
|
|
gptkbp:length
|
334 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17
17q24.3
|
|
gptkbp:molecularWeight
|
37.5 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
inflammatory diseases
|
|
gptkbp:OMIM
|
601268
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Map2k6
|
|
gptkbp:phosphorylates
|
gptkb:MAPK11
gptkb:MAPK12
gptkb:MAPK13
gptkb:MAPK14
Ser207
Thr211
|
|
gptkbp:proteinFamily
|
gptkb:MAP_kinase_kinase_family
|
|
gptkbp:regulates
|
gptkb:TAK1
gptkb:MAP3K1
gptkb:TAO2
gptkb:MAP3K2
gptkb:MAP3K3
gptkb:MAP3K4
gptkb:MAP3K5
gptkb:MAP3K6
gptkb:MAP3K7
cell differentiation
cell proliferation
cell survival
ASK1
TAO1
TAO3
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P52564
|
|
gptkbp:bfsParent
|
gptkb:MKK6
|
|
gptkbp:bfsLayer
|
7
|