|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
tyrosine-protein kinase
|
|
gptkbp:alternativeSplicing
|
produces two isoforms
|
|
gptkbp:associatedWith
|
gptkb:chronic_myelogenous_leukemia
gptkb:B_cell_lymphoma
gptkb:systemic_lupus_erythematosus
|
|
gptkbp:discoveredBy
|
1988
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:LYN
4067
|
|
gptkbp:enzymeCommissionNumber
|
2.7.10.2
|
|
gptkbp:expressedIn
|
gptkb:B_cells
hematopoietic cells
myeloid cells
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
signal transduction
phosphorylation of tyrosine residues
|
|
gptkbp:gene
|
gptkb:LYN
|
|
gptkbp:HGNC_ID
|
6737
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Lyn kinase
|
|
gptkbp:inhibitedBy
|
gptkb:bosutinib
gptkb:dasatinib
|
|
gptkbp:locatedOnChromosome
|
8q13.3
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
56 kDa
|
|
gptkbp:namedAfter
|
Lyn McAllister
|
|
gptkbp:orthologInMouse
|
gptkb:Lyn
|
|
gptkbp:PDB
|
gptkb:1QPC
|
|
gptkbp:phosphorylates
|
gptkb:CD22
gptkb:Syk
ITAM motifs
|
|
gptkbp:postTranslationalModification
|
palmitoylation
phosphorylation
myristoylation
|
|
gptkbp:proteinFamily
|
gptkb:Src_family_kinases
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
immune response
B cell receptor signaling
|
|
gptkbp:structure
|
kinase domain
SH2 domain
SH3 domain
|
|
gptkbp:UniProtID
|
P07948
|
|
gptkbp:bfsParent
|
gptkb:B_cell_receptor_signaling_pathway
|
|
gptkbp:bfsLayer
|
7
|