|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
immune system
|
|
gptkbp:biologicalProcess
|
signal transduction
phosphatase activity
immune response
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:compatibleWith
|
erythrocytes
non-hematopoietic cells
|
|
gptkbp:discoveredBy
|
gptkb:Thomas_Trowbridge
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodes
|
gptkb:CD45
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000081237
5788
|
|
gptkbp:expressedIn
|
gptkb:leukocytes
monocytes
lymphocytes
granulocytes
|
|
gptkbp:function
|
protein tyrosine phosphatase activity
regulation of T-cell and B-cell antigen receptor signaling
|
|
gptkbp:gene
|
gptkb:PTPRC
gptkb:protein_tyrosine_phosphatase,_receptor_type_C
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasIsoform
|
gptkb:CD45RA
gptkb:CD45RABC
gptkb:CD45RB
gptkb:CD45RC
gptkb:CD45RO
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:9666
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PTPRC
|
|
gptkbp:interactsWith
|
gptkb:ZAP-70
gptkb:CD3_complex
gptkb:Lck
|
|
gptkbp:length
|
1304
|
|
gptkbp:locatedOnChromosome
|
chromosome 1
1q31-q32
|
|
gptkbp:molecularWeight
|
~145-220 kDa
|
|
gptkbp:mutationAssociatedWith
|
immunodeficiency
|
|
gptkbp:OMIM
|
151460
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Ptprc
|
|
gptkbp:otherName
|
gptkb:CD45
gptkb:Leukocyte_common_antigen
|
|
gptkbp:product
|
receptor-type
|
|
gptkbp:proteinFamily
|
gptkb:protein_tyrosine_phosphatase_family
|
|
gptkbp:regulates
|
T cell activation
B cell activation
|
|
gptkbp:UniProtID
|
P08575
|
|
gptkbp:bfsParent
|
gptkb:protein_tyrosine_phosphatases
|
|
gptkbp:bfsLayer
|
6
|