|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:FLJ43556
gptkb:LDL_receptor-related_protein_6
gptkb:LRP7
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:bone
coronary artery disease
|
|
gptkbp:discoveredIn
|
1998
|
|
gptkbp:encodedBy
|
gptkb:LRP6_gene
|
|
gptkbp:Entrez_Gene_ID
|
4040
ENSG00000134970
|
|
gptkbp:expressedIn
|
gptkb:bone
brain
heart
liver
various tissues
|
|
gptkbp:fullName
|
gptkb:Low-density_lipoprotein_receptor-related_protein_6
|
|
gptkbp:function
|
regulation of cell differentiation
regulation of cell proliferation
co-receptor in Wnt signaling pathway
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasParalog
|
gptkb:LRP5
|
|
gptkbp:HGNC_ID
|
6694
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LRP6
|
|
gptkbp:interactsWith
|
gptkb:Axin
gptkb:Frizzled_receptors
gptkb:GSK3β
gptkb:Wnt_proteins
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12p13.2
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
161 kDa
|
|
gptkbp:mutationAssociatedWith
|
can cause early coronary artery disease
can cause familial tooth agenesis
|
|
gptkbp:OMIM
|
603507
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Lrp6
|
|
gptkbp:pathway
|
gptkb:beta-catenin_signaling_pathway
canonical Wnt signaling pathway
|
|
gptkbp:PDB
|
gptkb:2YRP
|
|
gptkbp:phosphorylates
|
gptkb:GSK3β
gptkb:casein_kinase_1_gamma
|
|
gptkbp:proteinFamily
|
gptkb:LDL_receptor_gene_family
|
|
gptkbp:symbol
|
gptkb:LRP6
|
|
gptkbp:UniProtID
|
O75581
|
|
gptkbp:bfsParent
|
gptkb:Frizzled/LRP5/6_receptor_complex
gptkb:LDL_receptor_class_A_domain
gptkb:Wnt_proteins
gptkb:DKK1
gptkb:LRP5/6
|
|
gptkbp:bfsLayer
|
7
|