Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:discoveredBy |
gptkb:Michael_S._Brown
gptkb:Joseph_L._Goldstein |
| gptkbp:domain |
EGF-like repeats
beta-propeller domain ligand-binding repeats |
| gptkbp:foundIn |
vertebrates
|
| gptkbp:function |
cell signaling
cholesterol homeostasis endocytosis of lipoproteins |
| https://www.w3.org/2000/01/rdf-schema#label |
LDL receptor gene family
|
| gptkbp:includes |
Low-density lipoprotein receptor-related protein 2 (LRP2/megalin)
Low-density lipoprotein receptor-related protein 1 (LRP1) Apolipoprotein E receptor 2 (ApoER2/LRP8) LDL receptor (LDLR) SORLA (LR11/LR12) VLDL receptor (VLDLR) Low-density lipoprotein receptor-related protein 5 (LRP5) Low-density lipoprotein receptor-related protein 6 (LRP6) |
| gptkbp:mutationAssociatedWith |
gptkb:Alzheimer's_disease
gptkb:familial_hypercholesterolemia |
| gptkbp:relatedTo |
gptkb:Wnt_signaling_pathway
atherosclerosis lipid metabolism receptor-mediated endocytosis |
| gptkbp:bfsParent |
gptkb:LRP6
|
| gptkbp:bfsLayer |
8
|