beta-catenin signaling pathway
GPTKB entity
Statements (34)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
signaling molecule
|
| gptkbp:activatedBy |
Wnt ligand binding
|
| gptkbp:alsoKnownAs |
Wnt/beta-catenin pathway
|
| gptkbp:cause |
activation of Wnt target genes
beta-catenin accumulation in cytoplasm beta-catenin translocation to nucleus |
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
gptkb:bone colorectal cancer hepatocellular carcinoma fibrosis |
| gptkbp:firstDescribed |
1990s
|
| https://www.w3.org/2000/01/rdf-schema#label |
beta-catenin signaling pathway
|
| gptkbp:inhibitedBy |
gptkb:sFRP_proteins
gptkb:ICAT gptkb:DKK1 |
| gptkbp:involves |
gptkb:APC_protein
gptkb:Axin gptkb:Dishevelled_proteins gptkb:Frizzled_receptors gptkb:TCF/LEF_transcription_factors gptkb:Wnt_proteins gptkb:beta-catenin GSK-3beta |
| gptkbp:regulates |
cell differentiation
cell proliferation embryonic development stem cell renewal |
| gptkbp:studiedIn |
cancer research
developmental biology stem cell biology |
| gptkbp:bfsParent |
gptkb:LRP6
gptkb:DVL1_gene |
| gptkbp:bfsLayer |
8
|