LDL receptor-related protein 6

URI: https://gptkb.org/entity/LDL_receptor-related_protein_6
GPTKB entity
Statements (34)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:gene
gptkbp:abbreviation gptkb:LRP6
gptkbp:alternativeSplicing yes
gptkbp:associatedWith coronary artery disease
tooth agenesis
bone density regulation
gptkbp:discoveredIn 1998
gptkbp:domain EGF-like domain
LDL-receptor class A domain
YWTD repeat domain
gptkbp:encodedBy gptkb:LRP6_gene
gptkbp:Entrez_Gene_ID ENSG00000134970
40437
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function regulation of cell signaling
co-receptor in Wnt signaling pathway
https://www.w3.org/2000/01/rdf-schema#label LDL receptor-related protein 6
gptkbp:interactsWith gptkb:Frizzled_receptors
gptkb:Wnt_proteins
gptkbp:locatedOnChromosome gptkb:chromosome_12p13.2
gptkbp:location gptkb:plasma_membrane
gptkbp:molecularWeight 161 kDa
gptkbp:OMIM 603507
gptkbp:orthologIn gptkb:Danio_rerio
gptkb:Mus_musculus
gptkbp:phosphorylates gptkb:GSK3β
CK1γ
gptkbp:relatedTo gptkb:Wnt/β-catenin_signaling
gptkb:LDL_receptor_family
gptkbp:structure single-pass type I membrane protein
gptkbp:UniProtID O75581
gptkbp:bfsParent gptkb:LRP6
gptkbp:bfsLayer 8