|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:BTEB2
gptkb:IKLF
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
|
|
gptkbp:binds
|
GC-rich DNA sequences
|
|
gptkbp:discoveredBy
|
Suzuki et al.
|
|
gptkbp:discoveredIn
|
1998
|
|
gptkbp:encodes
|
KLF5 protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000102554
688
|
|
gptkbp:expressedIn
|
epithelial cells
smooth muscle cells
|
|
gptkbp:fullName
|
Kruppel-like factor 5
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:6349
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Klf5
|
|
gptkbp:interactsWith
|
gptkb:c-Myc
gptkb:p53
gptkb:beta-catenin
Smad proteins
|
|
gptkbp:involvedIn
|
embryonic development
wound healing
intestinal homeostasis
|
|
gptkbp:length
|
457 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:13q22.1
|
|
gptkbp:modulatedBy
|
gptkb:Wnt_signaling
p53 pathway
TGF-beta signaling
|
|
gptkbp:molecularWeight
|
50 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
colorectal cancer
prostate cancer
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Klf5 (mouse)
|
|
gptkbp:phosphorylates
|
gptkb:PKC
gptkb:ERK
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
gptkb:cyclin_D1
gptkb:p21
gptkb:VEGF
gptkb:E-cadherin
gptkb:Kruppel-like_factors
apoptosis
cell proliferation
differentiation
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:UniProtID
|
gptkb:Q13887
|
|
gptkbp:bfsParent
|
gptkb:KLF5
|
|
gptkbp:bfsLayer
|
8
|