|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:alias
|
gptkb:K-Ras
gptkb:KRAS
gptkb:Kirsten_rat_sarcoma_viral_oncogene_homolog
|
|
gptkbp:decommissioned
|
GTPase-activating proteins (GAPs)
|
|
gptkbp:discoveredBy
|
gptkb:Robert_Weinberg
|
|
gptkbp:encodedBy
|
gptkb:KRAS_gene
|
|
gptkbp:Entrez_Gene_ID
|
3845
|
|
gptkbp:function
|
guanine nucleotide exchange factor
|
|
gptkbp:hasIsoform
|
gptkb:KRas4A
gptkb:KRas4B
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
KRas
|
|
gptkbp:involvedIn
|
cell differentiation
cell proliferation
cell survival
cell signaling
|
|
gptkbp:locatedIn
|
gptkb:cell_membrane
|
|
gptkbp:locatedOnChromosome
|
12p12.1
|
|
gptkbp:memberOf
|
gptkb:Ras_family
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
colorectal cancer
pancreatic cancer
oncogenic mutation
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
gptkb:Drosophila_melanogaster
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:regulates
|
gptkb:MAPK_pathway
gptkb:PI3K-AKT_pathway
|
|
gptkbp:target
|
gptkb:adagrasib
gptkb:sotorasib
anticancer drugs
|
|
gptkbp:UniProtID
|
gptkb:P01116
|
|
gptkbp:bfsParent
|
gptkb:M-Ras_proteins
gptkb:PF00057
gptkb:small_GTPase_family
gptkb:PF00071
gptkb:GTPase_proteins
|
|
gptkbp:bfsLayer
|
7
|