|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
CD119
IFNGR
IMD27
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
immunodeficiency
Mendelian susceptibility to mycobacterial disease
|
|
gptkbp:biologicalProcess
|
signal transduction
immune response
cytokine receptor activity
|
|
gptkbp:component
|
interferon-gamma receptor complex
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:Entrez_Gene_ID
|
3459
ENSG00000105374
|
|
gptkbp:expressedIn
|
gptkb:leukocytes
gptkb:T_cells
macrophages
|
|
gptkbp:externalLink
|
https://www.ncbi.nlm.nih.gov/gene/3459
https://www.uniprot.org/uniprot/P15260
|
|
gptkbp:fullName
|
Interferon gamma receptor 1
|
|
gptkbp:function
|
mediates immune response
receptor for interferon gamma
|
|
gptkbp:gene
|
gptkb:IFNGR1
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
5438
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IFNGR1
|
|
gptkbp:interactsWith
|
gptkb:STAT1
gptkb:interferon_gamma
gptkb:JAK1
gptkb:IFNGR2
|
|
gptkbp:length
|
489 amino acids
|
|
gptkbp:locatedOnChromosome
|
6q23.3
|
|
gptkbp:molecularWeight
|
53 kDa
|
|
gptkbp:mutationAssociatedWith
|
immunodeficiency
susceptibility to infections
|
|
gptkbp:OMIM
|
107470
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Ifngr1
|
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
cytokine-cytokine receptor interaction
|
|
gptkbp:PDB
|
3T0E
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:signalPeptide
|
present
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
|
|
gptkbp:transmembraneDomains
|
1
|
|
gptkbp:UniProtID
|
P15260
|
|
gptkbp:bfsParent
|
gptkb:JAK2
gptkb:STAT1
gptkb:interferon-gamma_receptor
gptkb:Th1_cells
|
|
gptkbp:bfsLayer
|
7
|