polycythemia vera

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:disease
myeloproliferative neoplasm
gptkbp:affects red blood cells
bone marrow
platelets
white blood cells
gptkbp:alternativeName gptkb:Vaquez_disease
gptkb:Osler-Vaquez_disease
primary polycythemia
gptkbp:causedBy gptkb:JAK2_V617F_mutation
gptkb:JAK2_exon_12_mutation
gptkbp:complication gptkb:acute_myeloid_leukemia
gptkb:myelofibrosis
gptkbp:firstDescribed 1892
gptkbp:hasDiagnosticMethod bone marrow biopsy
JAK2 mutation test
complete blood count
gptkbp:hasLabFinding elevated hematocrit
elevated hemoglobin
leukocytosis
low erythropoietin
thrombocytosis
gptkbp:hasOrphanetID gptkb:ORPHA729
https://www.w3.org/2000/01/rdf-schema#label polycythemia vera
gptkbp:ICD-10_code gptkb:D45
gptkbp:inheritance sporadic
not inherited
gptkbp:medianAge 60 years
gptkbp:MeSH_ID gptkb:D011110
gptkbp:mortalityRate increased risk
gptkbp:namedAfter gptkb:Louis_Henri_Vaquez
gptkb:William_Osler
gptkbp:OMIM 263300
gptkbp:pathology clonal proliferation of hematopoietic stem cells
gptkbp:prevalence rare
gptkbp:prognosis chronic
gptkbp:riskFactor male sex
advanced age
gptkbp:symptom gptkb:erythromelalgia
dizziness
headache
pruritus
splenomegaly
thrombosis
gptkbp:treatment gptkb:ruxolitinib
gptkb:aspirin
gptkb:hydroxyurea
phlebotomy
gptkbp:bfsParent gptkb:Osler-Vaquez_disease
gptkb:Jakavi
gptkbp:bfsLayer 5