|
gptkbp:instanceOf
|
gptkb:disease
gptkb:myeloproliferative_neoplasm
|
|
gptkbp:affects
|
red blood cells
bone marrow
platelets
white blood cells
|
|
gptkbp:alternativeName
|
gptkb:Vaquez_disease
gptkb:Osler-Vaquez_disease
primary polycythemia
|
|
gptkbp:causedBy
|
gptkb:JAK2_V617F_mutation
gptkb:JAK2_exon_12_mutation
|
|
gptkbp:complication
|
gptkb:acute_myeloid_leukemia
gptkb:myelofibrosis
|
|
gptkbp:firstDescribed
|
1892
|
|
gptkbp:hasDiagnosticMethod
|
bone marrow biopsy
JAK2 mutation test
complete blood count
|
|
gptkbp:hasLabFinding
|
elevated hematocrit
elevated hemoglobin
leukocytosis
low erythropoietin
thrombocytosis
|
|
gptkbp:hasOrphanetID
|
gptkb:ORPHA729
|
|
gptkbp:ICD-10_code
|
gptkb:D45
|
|
gptkbp:inheritance
|
sporadic
not inherited
|
|
gptkbp:medianAge
|
60 years
|
|
gptkbp:MeSH_ID
|
gptkb:D011110
|
|
gptkbp:mortalityRate
|
increased risk
|
|
gptkbp:namedAfter
|
gptkb:Louis_Henri_Vaquez
gptkb:William_Osler
|
|
gptkbp:OMIM
|
263300
|
|
gptkbp:pathology
|
clonal proliferation of hematopoietic stem cells
|
|
gptkbp:prevalence
|
rare
|
|
gptkbp:prognosis
|
chronic
|
|
gptkbp:riskFactor
|
male sex
advanced age
|
|
gptkbp:symptom
|
gptkb:erythromelalgia
dizziness
headache
pruritus
splenomegaly
thrombosis
|
|
gptkbp:treatment
|
gptkb:ruxolitinib
gptkb:aspirin
gptkb:hydroxyurea
phlebotomy
|
|
gptkbp:bfsParent
|
gptkb:Osler-Vaquez_disease
|
|
gptkbp:bfsLayer
|
5
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
polycythemia vera
|