Janus kinase 2, non-receptor tyrosine kinase

URI: https://gptkb.org/entity/Janus_kinase_2,_non-receptor_tyrosine_kinase
GPTKB entity
Statements (38)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alternativeName gptkb:JAK2
gptkb:Janus_kinase_2
JAK-2
gptkbp:associatedWith gptkb:polycythemia_vera
essential thrombocythemia
primary myelofibrosis
gptkbp:biologicalProcess protein phosphorylation
ATP binding
gptkbp:discoveredBy 1992
gptkbp:domain SH2 domain
protein kinase domain
FERM domain
gptkbp:encodedBy gptkb:JAK2_gene
gptkbp:enzymeCommissionNumber 2.7.10.2
gptkbp:function signal transduction
tyrosine kinase activity
gptkbp:HGNC_ID 6192
https://www.w3.org/2000/01/rdf-schema#label Janus kinase 2, non-receptor tyrosine kinase
gptkbp:involves gptkb:JAK-STAT_signaling_pathway
cytokine signaling
gptkbp:locatedIn gptkb:nucleus
gptkb:cytoplasm
gptkbp:locatedOnChromosome gptkb:9p24.1
gptkbp:mutationAssociatedWith gptkb:V617F
gptkbp:OMIM 147796
gptkbp:organism gptkb:Homo_sapiens
gptkbp:phosphorylates gptkb:STAT_proteins
cytokine receptors
gptkbp:product gptkb:JAK2_gene
gptkbp:regulates immune response
hematopoiesis
gptkbp:targetOfDrug gptkb:fedratinib
gptkb:ruxolitinib
gptkbp:UniProtID O60674
gptkbp:bfsParent gptkb:JAK2
gptkbp:bfsLayer 7