|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:JTK10
gptkb:Janus_kinase_2
tyrosine kinase JAK2
|
|
gptkbp:discoveredBy
|
Darnell JE Jr. et al.
|
|
gptkbp:encodes
|
Janus kinase 2 protein
|
|
gptkbp:Entrez_Gene_ID
|
3717
ENSG00000096968
|
|
gptkbp:expressedIn
|
hematopoietic cells
|
|
gptkbp:foundIn
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:fullName
|
gptkb:Janus_kinase_2
|
|
gptkbp:function
|
non-receptor tyrosine kinase
|
|
gptkbp:GO_term
|
gptkb:GO:0004713
gptkb:GO:0007259
|
|
gptkbp:hasTranscriptVariant
|
JAK2-201
JAK2-202
JAK2-203
|
|
gptkbp:HGNC_ID
|
gptkb:JAK2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
JAK2 gene
|
|
gptkbp:involvedIn
|
gptkb:JAK-STAT_signaling_pathway
cytokine signaling
|
|
gptkbp:length
|
1132 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:9p24.1
9
|
|
gptkbp:MIM_number
|
147796
|
|
gptkbp:molecularWeight
|
~120 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:V617F
gptkb:polycythemia_vera
essential thrombocythemia
primary myelofibrosis
|
|
gptkbp:OMIM
|
147796
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:4BBE
2B7A
|
|
gptkbp:phosphorylates
|
gptkb:STAT_proteins
|
|
gptkbp:regulates
|
gptkb:STAT1
gptkb:STAT3
gptkb:STAT5
|
|
gptkbp:relatedTo
|
leukemia
thrombosis
myeloproliferative neoplasms
|
|
gptkbp:reviewedBy
|
gptkb:GeneReviews
gptkb:OMIM
gptkb:UniProt
|
|
gptkbp:target
|
gptkb:fedratinib
gptkb:ruxolitinib
gptkb:momelotinib
gptkb:pacritinib
|
|
gptkbp:UniProtID
|
O60674
|
|
gptkbp:bfsParent
|
gptkb:JAK2
gptkb:Primary_Myelofibrosis
|
|
gptkbp:bfsLayer
|
7
|