|
gptkbp:instanceOf
|
gptkb:disease
hematologic disorder
|
|
gptkbp:affects
|
bone marrow
|
|
gptkbp:alsoKnownAs
|
agnogenic myeloid metaplasia
primary myelofibrosis
|
|
gptkbp:associatedWithMutation
|
gptkb:CALR
gptkb:JAK2
gptkb:MPL
|
|
gptkbp:canBePrimary
|
true
|
|
gptkbp:canBeSecondaryTo
|
gptkb:polycythemia_vera
essential thrombocythemia
|
|
gptkbp:cause
|
gptkb:anemia
bleeding
splenomegaly
thrombosis
gout
infections
thrombocytopenia
portal hypertension
cachexia
extramedullary hematopoiesis
hepatomegaly
leukopenia
osteosclerosis
|
|
gptkbp:characterizedBy
|
fibrosis of bone marrow
|
|
gptkbp:complication
|
gptkb:acute_myeloid_leukemia
|
|
gptkbp:diagnosedBy
|
bone marrow biopsy
blood smear
|
|
gptkbp:firstDescribed
|
1879
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
myelofibrosis
|
|
gptkbp:ICD-10_code
|
D47.4
|
|
gptkbp:managedBy
|
hematologist
|
|
gptkbp:medianAge
|
65 years
|
|
gptkbp:mortalityRate
|
high if untreated
|
|
gptkbp:prevalence
|
rare
|
|
gptkbp:prognosis
|
variable
|
|
gptkbp:riskFactor
|
male sex
older age
previous myeloproliferative neoplasm
|
|
gptkbp:symptom
|
fatigue
weight loss
night sweats
bone pain
abdominal discomfort
|
|
gptkbp:treatment
|
gptkb:fedratinib
gptkb:ruxolitinib
stem cell transplant
|
|
gptkbp:bfsParent
|
gptkb:Osler-Vaquez_disease
gptkb:Jakavi
|
|
gptkbp:bfsLayer
|
5
|