|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:JAK1
Janus kinase family member 1
tyrosine-protein kinase JAK1
|
|
gptkbp:associatedWith
|
immunodeficiency
autosomal dominant hereditary spastic paraplegia
|
|
gptkbp:encodedBy
|
gptkb:JAK1_gene
|
|
gptkbp:enzymeCommissionNumber
|
2.7.10.2
|
|
gptkbp:has_molecular_function
|
ATP binding
protein tyrosine kinase activity
|
|
gptkbp:HGNC_ID
|
6190
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Janus kinase 1
|
|
gptkbp:interactsWith
|
gptkb:STAT1
gptkb:STAT3
gptkb:STAT5
interleukin receptors
|
|
gptkbp:involved_in_biological_process
|
cell proliferation
immune response
cytokine-mediated signaling pathway
|
|
gptkbp:locatedIn
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
1p31.3
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:phosphorylates
|
gptkb:STAT_proteins
|
|
gptkbp:product
|
gptkb:JAK1_gene
|
|
gptkbp:proteinFamily
|
gptkb:Janus_kinase_family
|
|
gptkbp:targetOfDrug
|
gptkb:tofacitinib
gptkb:upadacitinib
gptkb:baricitinib
|
|
gptkbp:UniProtID
|
gptkb:P23458
|
|
gptkbp:bfsParent
|
gptkb:JAK1
|
|
gptkbp:bfsLayer
|
8
|