|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Antigen_NY-CO-13
gptkb:Phosphoprotein_p53
gptkb:Tumor_suppressor_p53
gptkb:Transformation-related_protein_53
|
|
gptkbp:associatedWith
|
gptkb:Li-Fraumeni_syndrome
various cancers
|
|
gptkbp:biologicalProcess
|
apoptosis
DNA repair
cellular senescence
cell cycle arrest
transcription factor activity
DNA-binding
|
|
gptkbp:citation
|
HGNC:11998
Ensembl:ENSG00000141510
GeneID:7157
KEGG:hsa:7157
OMIM:191170
Reactome:R-HSA-69541
UniProt:P23458
|
|
gptkbp:enzymeCommissionNumber
|
EC 3.1.21.2
|
|
gptkbp:function
|
tumor suppressor
regulates cell division
prevents genome mutation
|
|
gptkbp:gene
|
gptkb:TP53
|
|
gptkbp:hasIsoform
|
12
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P23458
|
|
gptkbp:length
|
393
|
|
gptkbp:locatedOnChromosome
|
17p13.1
|
|
gptkbp:mass
|
43903 Da
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
p53 signaling pathway
|
|
gptkbp:PDB
|
gptkb:2OCJ
gptkb:3KMD
1TUP
|
|
gptkbp:postTranslationalModification
|
phosphorylation
methylation
sumoylation
ubiquitination
acetylation
|
|
gptkbp:protein_name
|
gptkb:Cellular_tumor_antigen_p53
|
|
gptkbp:reviewedBy
|
yes
|
|
gptkbp:sequenceStatus
|
complete
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
mitochondrion
|
|
gptkbp:UniProtID
|
gptkb:P23458
|
|
gptkbp:bfsParent
|
gptkb:JAK1
|
|
gptkbp:bfsLayer
|
8
|