|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:virus
phosphorylation
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:herpes_simplex_encephalitis
gptkb:systemic_lupus_erythematosus
autoimmune disease
viral infection susceptibility
|
|
gptkbp:discoveredBy
|
Takaoka et al.
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:encodedBy
|
IRF3 gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000126456
|
|
gptkbp:formsComplexWith
|
gptkb:CBP/p300
gptkb:IRF7
|
|
gptkbp:fullName
|
Interferon regulatory factor 3
|
|
gptkbp:function
|
transcription factor
regulates type I interferon genes
|
|
gptkbp:gene
|
gptkb:IRF3
|
|
gptkbp:GO
|
GO:0003700
GO:0006366
GO:0006955
|
|
gptkbp:HGNC_ID
|
6120
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IRF3
|
|
gptkbp:interactsWith
|
gptkb:CBP/p300
gptkb:IKKε
gptkb:TBK1
gptkb:STING
gptkb:MAVS
TRIF
|
|
gptkbp:involvedIn
|
innate immune response
antiviral response
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
19q13.33
|
|
gptkbp:molecularWeight
|
47 kDa
|
|
gptkbp:OMIM
|
603734
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Bos_taurus
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
1J2F
|
|
gptkbp:phosphorylates
|
gptkb:IKKε
gptkb:TBK1
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:proteinFamily
|
Interferon regulatory factor family
|
|
gptkbp:RefSeq
|
NP_001562
|
|
gptkbp:regulates
|
gptkb:CXCL10
gptkb:ISG15
gptkb:OAS1
IFNB1
RSAD2
|
|
gptkbp:UniProtID
|
Q14653
|
|
gptkbp:bfsParent
|
gptkb:IKKε
gptkb:TBK1
gptkb:RIG-I_signaling_pathway
gptkb:RIG-I-like_receptor_signaling_pathway
gptkb:STING
|
|
gptkbp:bfsLayer
|
8
|