|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
ISGF3G
IRF-7
interferon regulatory factor 7
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:associatedWith
|
gptkb:systemic_lupus_erythematosus
viral infection response
|
|
gptkbp:biologicalProcess
|
DNA binding
transcription factor activity
|
|
gptkbp:discoveredBy
|
Takaoka et al.
|
|
gptkbp:discoveredIn
|
1999
|
|
gptkbp:encodedBy
|
IRF7 gene
|
|
gptkbp:Entrez_Gene_ID
|
3665
ENSG00000185507
|
|
gptkbp:expressedIn
|
gptkb:plasmacytoid_dendritic_cells
immune cells
|
|
gptkbp:fullName
|
Interferon regulatory factor 7
|
|
gptkbp:function
|
regulation of type I interferon-dependent immune responses
transcriptional activation of interferon alpha and beta genes
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
6122
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IRF7
|
|
gptkbp:interactsWith
|
gptkb:IKKε
gptkb:TBK1
gptkb:TRAF6
gptkb:IRF3
MyD88
|
|
gptkbp:length
|
503
|
|
gptkbp:locatedOnChromosome
|
gptkb:11p15.5
chromosome 11
|
|
gptkbp:memberOf
|
gptkb:interferon_regulatory_factor_family
|
|
gptkbp:OMIM
|
605047
|
|
gptkbp:orthologInMouse
|
Irf7
|
|
gptkbp:phosphorylates
|
gptkb:IKKε
gptkb:TBK1
|
|
gptkbp:regulates
|
gptkb:IFNB1_gene
IFNA genes
activated by Toll-like receptor signaling
activated by viral infection
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
Q92985
|
|
gptkbp:bfsParent
|
gptkb:IKKε
gptkb:TBK1
gptkb:RIG-I-like_receptor_signaling_pathway
|
|
gptkbp:bfsLayer
|
8
|