OAS1

GPTKB entity

Statements (54)
Predicate Object
gptkbp:instanceOf gptkb:gene
gptkbp:alias gptkb:OAS
p40
OIAS
gptkbp:alternativeSplicing yes
gptkbp:associatedWith gptkb:OAS2
gptkb:OAS3
gptkb:systemic_lupus_erythematosus
gptkb:OASL
multiple sclerosis
autoimmune diseases
COVID-19 severity
viral infection susceptibility
interferon pathway
gptkbp:biologicalProcess ATP binding
nucleotidyltransferase activity
defense response to virus
interferon signaling pathway
gptkbp:discoveredBy Jean-Luc Battini et al.
gptkbp:encodes 2'-5'-oligoadenylate synthetase 1
gptkbp:Entrez_Gene_ID 4938
ENSG00000122786
gptkbp:expressedIn gptkb:leukocytes
gptkb:cancer
liver
spleen
gptkbp:firstDescribed 1980s
gptkbp:fullName 2'-5'-oligoadenylate synthetase 1
gptkbp:function innate immune response
antiviral response
gptkbp:geneType protein-coding
gptkbp:hasPolymorphism rs10774671
rs1131454
rs2660
gptkbp:HGNC_ID gptkb:8086
https://www.w3.org/2000/01/rdf-schema#label OAS1
gptkbp:length 400 amino acids (canonical isoform)
gptkbp:locatedOnChromosome gptkb:chromosome_12
gptkbp:OMIM 164350
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn Oas1 (mouse)
gptkbp:orthologInChimpanzee gptkb:OAS1
gptkbp:orthologInMouse Oas1
Oas1a
gptkbp:pathway gptkb:RIG-I-like_receptor_signaling_pathway
cytokine signaling in immune system
gptkbp:proteinFamily 2-5A synthetase family
gptkbp:regulates induced by interferons
gptkbp:subcellularLocation gptkb:nucleus
gptkb:cytoplasm
gptkbp:UniProtID P00973
gptkbp:bfsParent gptkb:2'-5'-oligoadenylate_synthetase_family
gptkb:Interferon-stimulated_gene
gptkbp:bfsLayer 7