|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:OAS
p40
OIAS
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:OAS2
gptkb:OAS3
gptkb:systemic_lupus_erythematosus
gptkb:OASL
multiple sclerosis
autoimmune diseases
COVID-19 severity
viral infection susceptibility
interferon pathway
|
|
gptkbp:biologicalProcess
|
ATP binding
nucleotidyltransferase activity
defense response to virus
interferon signaling pathway
|
|
gptkbp:discoveredBy
|
Jean-Luc Battini et al.
|
|
gptkbp:encodes
|
2'-5'-oligoadenylate synthetase 1
|
|
gptkbp:Entrez_Gene_ID
|
4938
ENSG00000122786
|
|
gptkbp:expressedIn
|
gptkb:leukocytes
gptkb:cancer
liver
spleen
|
|
gptkbp:firstDescribed
|
1980s
|
|
gptkbp:fullName
|
2'-5'-oligoadenylate synthetase 1
|
|
gptkbp:function
|
innate immune response
antiviral response
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasPolymorphism
|
rs10774671
rs1131454
rs2660
|
|
gptkbp:HGNC_ID
|
gptkb:8086
|
|
gptkbp:length
|
400 amino acids (canonical isoform)
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
|
|
gptkbp:OMIM
|
164350
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Oas1 (mouse)
|
|
gptkbp:orthologInChimpanzee
|
gptkb:OAS1
|
|
gptkbp:orthologInMouse
|
Oas1
Oas1a
|
|
gptkbp:pathway
|
gptkb:RIG-I-like_receptor_signaling_pathway
cytokine signaling in immune system
|
|
gptkbp:proteinFamily
|
2-5A synthetase family
|
|
gptkbp:regulates
|
induced by interferons
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
P00973
|
|
gptkbp:bfsParent
|
gptkb:2'-5'-oligoadenylate_synthetase_family
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
OAS1
|