|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:NAK
NF-kappa-B-activating kinase
|
|
gptkbp:associatedWith
|
amyotrophic lateral sclerosis
frontotemporal dementia
|
|
gptkbp:discoveredBy
|
Shizuo Akira
|
|
gptkbp:discoveredIn
|
1999
|
|
gptkbp:encodedBy
|
TBK1 gene
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:expressedIn
|
ubiquitous
|
|
gptkbp:fullName
|
TANK-binding kinase 1
|
|
gptkbp:function
|
serine/threonine-protein kinase
NF-kappaB signaling
phosphorylation of IRF3 and IRF7
regulation of innate immune response
|
|
gptkbp:gene
|
gptkb:TBK1
|
|
gptkbp:HGNC_ID
|
11584
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TBK1
|
|
gptkbp:interactsWith
|
gptkb:TANK
gptkb:OPTN
gptkb:TRAF2
TRAF3
|
|
gptkbp:KEGGID
|
hsa:29110
|
|
gptkbp:locatedOnChromosome
|
12q14.2
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
84 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:ALS
gptkb:FTD
|
|
gptkbp:OMIM
|
604834
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
4IM2
5W5V
|
|
gptkbp:phosphorylates
|
gptkb:p62/SQSTM1
gptkb:OPTN
gptkb:IRF3
gptkb:IRF7
|
|
gptkbp:RefSeq
|
NM_013254
|
|
gptkbp:regulates
|
autophagy
type I interferon production
|
|
gptkbp:UniProtID
|
Q9UHD2
|
|
gptkbp:bfsParent
|
gptkb:BX-795
|
|
gptkbp:bfsLayer
|
7
|