Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
gptkb:NF-κB
gptkb:IRF3 type I interferon response |
| gptkbp:alias |
gptkb:MITA
ERIS MPYS TMEM173 |
| gptkbp:associatedWith |
autoimmune diseases
inflammatory diseases antiviral immunity |
| gptkbp:binds |
cyclic GMP-AMP (cGAMP)
cyclic di-AMP cyclic di-GMP |
| gptkbp:discoveredBy |
Glen N. Barber
|
| gptkbp:discoveredIn |
2008
|
| gptkbp:encodedBy |
TMEM173 gene
|
| gptkbp:fullName |
Stimulator of Interferon Genes
|
| gptkbp:function |
innate immune signaling
cyclic dinucleotide sensing |
| gptkbp:gene |
TMEM173
|
| https://www.w3.org/2000/01/rdf-schema#label |
STING
|
| gptkbp:involvedIn |
innate immunity
host defense DNA sensing cGAS-STING pathway |
| gptkbp:locale |
gptkb:endoplasmic_reticulum
gptkb:Golgi_apparatus |
| gptkbp:locatedOnChromosome |
5q31.2
|
| gptkbp:mutationAssociatedWith |
autoinflammatory diseases
SAVI (STING-associated vasculopathy with onset in infancy) lupus-like syndromes |
| gptkbp:orthologIn |
gptkb:fish
birds amphibians mammals reptiles |
| gptkbp:PDB |
4LOH
6NT7 6NT8 6NT9 6NTB |
| gptkbp:phosphorylates |
gptkb:TBK1
|
| gptkbp:species |
gptkb:Mus_musculus
gptkb:Homo_sapiens |
| gptkbp:structure |
transmembrane protein
|
| gptkbp:target |
cancer immunotherapy research
small molecule agonists small molecule antagonists |
| gptkbp:UniProtID |
Q86WV6
|
| gptkbp:bfsParent |
gptkb:Malaysian_Special_Forces
|
| gptkbp:bfsLayer |
7
|