hypoxia inducible factor 1 subunit alpha

URI: https://gptkb.org/entity/hypoxia_inducible_factor_1_subunit_alpha
GPTKB entity
Statements (32)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:HIF-1α
basic helix-loop-helix PAS domain-containing protein
gptkbp:associatedWith gptkb:cancer
ischemia
gptkbp:degradation_regulated_by oxygen levels
gptkbp:degradedBy gptkb:proteasome
gptkbp:discoveredBy gptkb:Gregg_L._Semenza
gptkbp:Entrez_Gene_ID 3091
ENSG00000100644
gptkbp:expressedIn many tissues
gptkbp:firstDescribed 1995
gptkbp:formsComplexWith hypoxia inducible factor 1 subunit beta
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function transcription factor
regulation of response to hypoxia
gptkbp:gene gptkb:HIF1A
https://www.w3.org/2000/01/rdf-schema#label hypoxia inducible factor 1 subunit alpha
gptkbp:interactsWith gptkb:von_Hippel-Lindau_protein
gptkbp:locatedIn gptkb:nucleus
gptkbp:locatedOnChromosome 14q23.2
gptkbp:molecularWeight ~93 kDa
gptkbp:PDB 1H2M
gptkbp:postTranslationalModification ubiquitination
hydroxylation
gptkbp:regulates VEGF expression
expression of hypoxia-responsive genes
erythropoietin expression
glycolytic enzyme expression
gptkbp:UniProtID Q16665
gptkbp:bfsParent gptkb:HIF1A
gptkbp:bfsLayer 7