|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:SLC2A1
gptkb:solute_carrier_family_2_member_1
GLUT-1
erythrocyte glucose transporter
|
|
gptkbp:associatedWith
|
gptkb:GLUT1_deficiency_syndrome
epilepsy
developmental delay
|
|
gptkbp:clinicalTrialPhase
|
genetic testing
CSF glucose measurement
|
|
gptkbp:discoveredBy
|
Mueckler et al.
|
|
gptkbp:discoveredIn
|
1985
|
|
gptkbp:encodedBy
|
gptkb:SLC2A1
|
|
gptkbp:Entrez_Gene_ID
|
6513
|
|
gptkbp:expressedIn
|
gptkb:placenta
gptkb:blood-brain_barrier
endothelial cells
erythrocytes
|
|
gptkbp:foundIn
|
gptkb:cell_membrane
|
|
gptkbp:fullName
|
gptkb:Glucose_transporter_type_1
|
|
gptkbp:function
|
facilitated glucose transport
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
11005
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GLUT1
|
|
gptkbp:inhibitedBy
|
gptkb:cytochalasin_B
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p34.2
|
|
gptkbp:molecularWeight
|
54 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:GLUT1_deficiency_syndrome
gptkb:hereditary_spastic_paraplegia
|
|
gptkbp:OMIM
|
138140
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
glycolysis
glucose transport
central nervous system energy metabolism
|
|
gptkbp:PDB
|
4PYP
|
|
gptkbp:proteinFamily
|
gptkb:solute_carrier_family
gptkb:glucose_transporter_family
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structureType
|
integral membrane protein
|
|
gptkbp:subcellularLocation
|
gptkb:plasma_membrane
microvessel endothelium
|
|
gptkbp:therapeuticApproach
|
gptkb:ketogenic_diet
|
|
gptkbp:tissue_specificity
|
high in brain
high in erythrocytes
|
|
gptkbp:transmembraneDomains
|
12
|
|
gptkbp:transportSubstrate
|
gptkb:dehydroascorbic_acid
glucose
|
|
gptkbp:UniProtID
|
P11166
|
|
gptkbp:bfsParent
|
gptkb:HIF-1α
gptkb:HIF1A
gptkb:Glucose_transporter
gptkb:SLC2A1
|
|
gptkbp:bfsLayer
|
7
|