|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:LDH-A
gptkb:LDH-M
gptkb:cellular_lactate_dehydrogenase_A_chain
|
|
gptkbp:associatedWith
|
gptkb:LDHA_deficiency
cancer metabolism
lactic acidosis
|
|
gptkbp:biologicalProcess
|
glycolytic process
cellular response to hypoxia
|
|
gptkbp:encodes
|
gptkb:lactate_dehydrogenase_A_chain
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000134333
3939
|
|
gptkbp:enzymeCommissionNumber
|
1.1.1.27
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
gptkb:testis
embryonic development
liver
adult life
|
|
gptkbp:fullName
|
gptkb:lactate_dehydrogenase_A
|
|
gptkbp:function
|
catalyzes conversion of pyruvate to lactate
involved in anaerobic glycolysis
lactate dehydrogenase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOMolecularFunction
|
NAD binding
pyruvate binding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
6541
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LDHA
|
|
gptkbp:inhibitedBy
|
gptkb:oxamate
gptkb:FX11
|
|
gptkbp:length
|
332 amino acids
|
|
gptkbp:locatedOnChromosome
|
chromosome 11
11p15.4
|
|
gptkbp:molecularWeight
|
36.5 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:LDHA_deficiency
|
|
gptkbp:OMIM
|
150000
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Ldha
|
|
gptkbp:pathway
|
gptkb:pyruvate_metabolism
glycolysis
|
|
gptkbp:PDB
|
gptkb:4AJP
1I10
|
|
gptkbp:regulates
|
gptkb:HIF1A
gptkb:MYC
|
|
gptkbp:significance
|
marker for tissue damage
biomarker for cancer
|
|
gptkbp:subunit
|
homotetramer
heterotetramer with LDHB
|
|
gptkbp:UniProtID
|
gptkb:P00338
|
|
gptkbp:bfsParent
|
gptkb:LDH
gptkb:lactate_dehydrogenase
|
|
gptkbp:bfsLayer
|
6
|