|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:HEL-S-68p
gptkb:PGKA
gptkb:cell_migration-inducing_gene_10_protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:anemia
muscular dystrophy
neurological dysfunction
phosphoglycerate kinase deficiency
|
|
gptkbp:biologicalProcess
|
ATP binding
glycolytic process
cellular response to hypoxia
phosphoglycerate kinase activity
|
|
gptkbp:catalyzes
|
1,3-bisphosphoglycerate + ADP → 3-phosphoglycerate + ATP
|
|
gptkbp:clinicalTrialPhase
|
enzyme activity assay
|
|
gptkbp:encodes
|
gptkb:phosphoglycerate_kinase_1_protein
|
|
gptkbp:Entrez_Gene_ID
|
5230
ENSG00000102144
|
|
gptkbp:enzyme
|
phosphoglycerate kinase activity
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
erythrocytes
|
|
gptkbp:fullName
|
gptkb:phosphoglycerate_kinase_1
|
|
gptkbp:function
|
glycolysis
|
|
gptkbp:hasPseudogene
|
gptkb:PGK2
|
|
gptkbp:HGNC_ID
|
8896
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PGK1
|
|
gptkbp:length
|
417 amino acids
|
|
gptkbp:locatedOnChromosome
|
X
|
|
gptkbp:molecularWeight
|
44.5 kDa
|
|
gptkbp:mutationAssociatedWith
|
enzyme deficiency
X-linked inheritance
|
|
gptkbp:OMIM
|
300653
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Pgk1
|
|
gptkbp:orthologInYeast
|
gptkb:PGK1
|
|
gptkbp:pathway
|
glycolysis
gluconeogenesis
|
|
gptkbp:PDB
|
gptkb:2XE7
gptkb:1PHP
gptkb:3C39
|
|
gptkbp:product
|
monomer
|
|
gptkbp:regulates
|
regulated by HIF1A
upregulated by hypoxia
|
|
gptkbp:significance
|
biomarker for cancer
potential therapeutic target
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:tissue_specificity
|
ubiquitous
|
|
gptkbp:UniProtID
|
gptkb:P00558
|
|
gptkbp:bfsParent
|
gptkb:phosphoglycerate_kinase
gptkb:HIF1A
|
|
gptkbp:bfsLayer
|
7
|