|
gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:pVHL
von Hippel-Lindau tumor suppressor
|
|
gptkbp:associatedWith
|
gptkb:hereditary_cancer_syndrome
|
|
gptkbp:binds
|
gptkb:RBX1
elongin B
elongin C
CUL2
|
|
gptkbp:degradationTarget
|
HIF-α subunits
|
|
gptkbp:discoveredBy
|
gptkb:Gregg_L._Semenza
gptkb:Peter_J._Ratcliffe
gptkb:William_G._Kaelin_Jr.
|
|
gptkbp:encodedBy
|
gptkb:VHL_gene
|
|
gptkbp:Entrez_Gene_ID
|
7428
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
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gptkbp:function
|
gptkb:tumor_suppressor
E3 ubiquitin ligase complex component
|
|
gptkbp:interactsWith
|
gptkb:fibronectin
gptkb:p53
tubulin
Jade-1
|
|
gptkbp:involvedIn
|
ubiquitination
hypoxia response
|
|
gptkbp:locatedOnChromosome
|
3p25-26
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
24 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:hemangioblastoma
gptkb:pheochromocytoma
gptkb:von_Hippel-Lindau_disease
gptkb:pancreatic_neuroendocrine_tumors
clear cell renal cell carcinoma
|
|
gptkbp:NobelPrizeYear
|
gptkb:2019_Nobel_Prize_in_Physiology_or_Medicine
|
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gptkbp:OMIM
|
608537
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:1LM8
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
apoptosis
angiogenesis
cell cycle
cell adhesion
extracellular matrix formation
|
|
gptkbp:structure
|
alpha domain
beta domain
|
|
gptkbp:target
|
gptkb:HIF-1α
gptkb:HIF-2α
|
|
gptkbp:UniProtID
|
P40337
|
|
gptkbp:bfsParent
|
gptkb:HIF-1α
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
VHL protein
|