VHL protein

GPTKB entity

Statements (57)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:pVHL
von Hippel-Lindau tumor suppressor
gptkbp:associatedWith hereditary cancer syndrome
gptkbp:binds gptkb:RBX1
elongin B
elongin C
CUL2
gptkbp:degradationTarget HIF-α subunits
gptkbp:discoveredBy gptkb:Gregg_L._Semenza
gptkb:Peter_J._Ratcliffe
gptkb:William_G._Kaelin_Jr.
gptkbp:encodedBy gptkb:VHL_gene
gptkbp:Entrez_Gene_ID 7428
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function tumor suppressor
E3 ubiquitin ligase complex component
https://www.w3.org/2000/01/rdf-schema#label VHL protein
gptkbp:interactsWith gptkb:fibronectin
gptkb:p53
tubulin
Jade-1
gptkbp:involvedIn ubiquitination
hypoxia response
gptkbp:locatedOnChromosome 3p25-26
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:molecularWeight 24 kDa
gptkbp:mutationAssociatedWith gptkb:hemangioblastoma
gptkb:pheochromocytoma
gptkb:von_Hippel-Lindau_disease
gptkb:pancreatic_neuroendocrine_tumors
clear cell renal cell carcinoma
gptkbp:NobelPrizeYear gptkb:2019_Nobel_Prize_in_Physiology_or_Medicine
gptkbp:OMIM 608537
gptkbp:orthologIn gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkb:Rattus_norvegicus
gptkbp:PDB gptkb:1LM8
gptkbp:postTranslationalModification phosphorylation
ubiquitination
gptkbp:regulates apoptosis
angiogenesis
cell cycle
cell adhesion
extracellular matrix formation
gptkbp:structure alpha domain
beta domain
gptkbp:target gptkb:HIF-1α
gptkb:HIF-2α
gptkbp:UniProtID P40337
gptkbp:bfsParent gptkb:HIF-1α
gptkb:VHL_gene
gptkb:HIF1A
gptkb:Von_Hippel-Lindau_tumor_suppressor
gptkbp:bfsLayer 7