|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatesTranscriptionOf
|
gptkb:EPO_gene
gptkb:VEGF_gene
gptkb:GLUT1_gene
|
|
gptkbp:alias
|
gptkb:HIF1A
gptkb:bHLHe78
|
|
gptkbp:associatedWith
|
gptkb:cancer
inflammation
ischemia
|
|
gptkbp:degradedBy
|
gptkb:proteasome
gptkb:VHL_protein
oxygen levels
|
|
gptkbp:discoveredBy
|
gptkb:Gregg_L._Semenza
|
|
gptkbp:discoveredIn
|
1995
|
|
gptkbp:encodedBy
|
gptkb:HIF1A_gene
|
|
gptkbp:formsComplexWith
|
HIF-1β protein
|
|
gptkbp:fullName
|
gptkb:Hypoxia-inducible_factor_1-alpha
|
|
gptkbp:function
|
transcription factor
regulates response to hypoxia
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HIF-1α protein
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
14q23.2
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
1H2K
|
|
gptkbp:postTranslationalModification
|
ubiquitination
hydroxylation
|
|
gptkbp:regulates
|
angiogenesis
glycolysis
erythropoiesis
cell survival under hypoxia
|
|
gptkbp:structure
|
transactivation domain
PAS domain
basic helix-loop-helix domain
|
|
gptkbp:UniProtID
|
Q16665
|
|
gptkbp:bfsParent
|
gptkb:HIF1A
|
|
gptkbp:bfsLayer
|
7
|