hypoxia-inducible factor 1 (HIF-1)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:transcription_factor gptkb:protein
gptkbp:activatedBy	low oxygen levels
gptkbp:associatedWith	inflammation tumor growth ischemia
gptkbp:binds	gptkb:hypoxia_response_elements_(HREs)
gptkbp:composedOf	gptkb:HIF-1α gptkb:HIF-1β
gptkbp:degradedBy	gptkb:proteasome gptkb:von_Hippel-Lindau_protein_(VHL)
gptkbp:discoveredBy	gptkb:Gregg_L._Semenza
gptkbp:firstDescribed	1995
gptkbp:function	regulation of cellular response to hypoxia
gptkbp:gene	gptkb:ARNT gptkb:HIF1A
gptkbp:GO	GO:0001666 (response to hypoxia)
gptkbp:inhibitedBy	normoxia
gptkbp:locale	cell nucleus
gptkbp:OMIM	603348
gptkbp:PDB	1H2M
gptkbp:postTranslationalModification	ubiquitination hydroxylation
gptkbp:regulates	gptkb:erythropoietin_gene gptkb:glucose_transporter_1_(GLUT1) gptkb:vascular_endothelial_growth_factor_(VEGF) expression of hypoxia-responsive genes
gptkbp:role	angiogenesis cancer progression erythropoiesis cell survival under hypoxia metabolic adaptation
gptkbp:species	gptkb:Mus_musculus gptkb:Homo_sapiens
gptkbp:subunit	gptkb:HIF_family
gptkbp:target	gptkb:cancer anemia therapy
gptkbp:UniProtID	P27540 (HIF-1β) Q16665 (HIF-1α)
gptkbp:bfsParent	gptkb:Warburg_effect
gptkbp:bfsLayer	6
https://www.w3.org/2000/01/rdf-schema#label	hypoxia-inducible factor 1 (HIF-1)