hypoxia-inducible factor 1 (HIF-1)

URI: https://gptkb.org/entity/hypoxia-inducible_factor_1_(HIF-1)
GPTKB entity
Statements (42)
Predicate Object
gptkbp:instanceOf gptkb:protein
transcription factor
gptkbp:activatedBy low oxygen levels
gptkbp:associatedWith inflammation
tumor growth
ischemia
gptkbp:binds gptkb:hypoxia_response_elements_(HREs)
gptkbp:composedOf gptkb:HIF-1α
gptkb:HIF-1β
gptkbp:degradedBy gptkb:proteasome
gptkb:von_Hippel-Lindau_protein_(VHL)
gptkbp:discoveredBy gptkb:Gregg_L._Semenza
gptkbp:firstDescribed 1995
gptkbp:function regulation of cellular response to hypoxia
gptkbp:gene gptkb:ARNT
gptkb:HIF1A
gptkbp:GO GO:0001666 (response to hypoxia)
https://www.w3.org/2000/01/rdf-schema#label hypoxia-inducible factor 1 (HIF-1)
gptkbp:inhibitedBy normoxia
gptkbp:locale cell nucleus
gptkbp:OMIM 603348
gptkbp:PDB 1H2M
gptkbp:postTranslationalModification ubiquitination
hydroxylation
gptkbp:regulates gptkb:erythropoietin_gene
gptkb:glucose_transporter_1_(GLUT1)
gptkb:vascular_endothelial_growth_factor_(VEGF)
expression of hypoxia-responsive genes
gptkbp:role angiogenesis
cancer progression
erythropoiesis
cell survival under hypoxia
metabolic adaptation
gptkbp:species gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkbp:subunit gptkb:HIF_family
gptkbp:target gptkb:cancer
anemia therapy
gptkbp:UniProtID P27540 (HIF-1β)
Q16665 (HIF-1α)
gptkbp:bfsParent gptkb:Warburg_effect
gptkbp:bfsLayer 5