FISH (fluorescence in situ hybridization)
GPTKB entity
Statements (97)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
molecular biology technique
|
| gptkbp:appliesTo |
tissue sections
metaphase chromosomes interphase nuclei whole cells |
| gptkbp:canBe |
gptkb:chromosome_painting
environmental microbiology biodiversity studies microbial communities animal cells plant cells ecological studies phylogenetic studies preimplantation genetic diagnosis microbial identification blood smears identification of parasites monitoring minimal residual disease prenatal diagnosis gene mapping yeast cells amniotic fluid cells bacterial cells bone marrow samples chorionic villus samples cultured cells formalin-fixed paraffin-embedded samples fresh samples hematological malignancy diagnosis identification of CRISPR modifications identification of X chromosome sequences identification of Y chromosome sequences identification of aneuploidy identification of autosomal aneuploidy identification of centromere position identification of centromeric DNA identification of chimerism identification of chromosomal rearrangements identification of copy number variations identification of fragile sites identification of gene breakpoints identification of gene editing events identification of gene fusions identification of gene therapy outcomes identification of germline mutations identification of loss of heterozygosity identification of marker chromosomes identification of microdeletions identification of microduplications identification of mitochondrial DNA identification of monosomy identification of mosaicism identification of pathogenic bacteria identification of pathogenic fungi identification of polyploidy identification of protozoa identification of repetitive DNA sequences identification of ribosomal RNA genes identification of satellite DNA identification of segmental duplications identification of sex chromosome aneuploidy identification of single-copy DNA sequences identification of somatic mutations identification of telomere length identification of telomeric DNA identification of transgenic organisms identification of trisomy identification of uniparental disomy identification of viral integration sites identification of viruses solid tumor diagnosis sperm cells |
| gptkbp:detects |
nucleic acids
|
| gptkbp:developedBy |
1980s
|
| gptkbp:enables |
detection of gene amplifications
detection of gene deletions detection of gene inversions detection of gene translocations |
| https://www.w3.org/2000/01/rdf-schema#label |
FISH (fluorescence in situ hybridization)
|
| gptkbp:relatedTo |
gptkb:DNA_FISH
gptkb:RNA_FISH gptkb:chromosome_painting comparative genomic hybridization |
| gptkbp:supportsProtocol |
washing
hybridization detection denaturation |
| gptkbp:usedFor |
cancer diagnosis
gene expression analysis chromosome mapping diagnosis of genetic diseases detecting and localizing specific DNA sequences identification of chromosomal abnormalities |
| gptkbp:uses |
fluorescent probes
|
| gptkbp:visualizes |
fluorescence microscopy
|
| gptkbp:bfsParent |
gptkb:Cri-du-chat_syndrome
|
| gptkbp:bfsLayer |
6
|