Herceptin

GPTKB entity

Statements (54)
Predicate Object
gptkbp:instance_of gptkb:monoclonal_antibody
gptkbp:administered_by intravenous infusion
gptkbp:approves gptkb:1998
gptkb:FDA
gptkbp:bioavailability gptkb:trastuzumab-dkst
gptkb:trastuzumab-pkrb
gptkb:trastuzumab-qyzy
gptkbp:can_be_combined_with gptkb:docetaxel
gptkb:pertuzumab
gptkb:carboplatin
chemotherapy
gptkbp:chemical_formula C6475 H10000 N1715 O2100 S44
gptkbp:clinical_trial Phase III
gptkbp:contraindication pregnancy
lactation
hypersensitivity to trastuzumab
gptkbp:developed_by gptkb:Genentech
gptkbp:discontinued in patients with severe heart failure
https://www.w3.org/2000/01/rdf-schema#label Herceptin
gptkbp:indication gptkb:HER2-positive_breast_cancer
HER2-positive gastric cancer
gptkbp:invention gptkb:2019
gptkbp:is_monitored_by cardiac function
infusion reactions
gptkbp:marketed_as gptkb:Europe
gptkb:Australia
gptkb:Canada
gptkb:United_States
gptkb:trastuzumab
gptkbp:mechanism_of_action HER2 receptor blockade
gptkbp:patient_population gptkb:children
adults
gptkbp:price high
gptkbp:provides_guidance_on ASCO guidelines
NCCN guidelines
gptkbp:requires available online
gptkbp:research_areas gptkb:biotechnology
gptkb:pharmaceuticals
gptkb:immunotherapy
oncology
gptkbp:route_of_administration intravenous
gptkbp:shelf_life 24 months
gptkbp:side_effect headache
nausea
diarrhea
infusion reactions
cardiotoxicity
gptkbp:storage 2 to 8 ° C
gptkbp:targets HER2 protein
gptkbp:used_for treatment of breast cancer
treatment of gastric cancer
gptkbp:weight 148 k Da
gptkbp:bfsParent gptkb:Genentech
gptkbp:bfsLayer 4