Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:binds |
gptkb:GTP
|
| gptkbp:component |
microtubule
|
| gptkbp:conservedIn |
animals
fungi plants |
| gptkbp:discoveredIn |
1960s
|
| gptkbp:encodedBy |
TUBA1A gene
|
| gptkbp:expressedIn |
all eukaryotic cells
|
| gptkbp:form |
microtubule lattice
protofilament |
| gptkbp:formsHeterodimerWith |
beta-tubulin
|
| gptkbp:foundIn |
eukaryotic cell
|
| gptkbp:function |
cell division
cytoskeleton organization intracellular transport |
| gptkbp:GO |
GO:0005884
|
| https://www.w3.org/2000/01/rdf-schema#label |
alpha-tubulin
|
| gptkbp:hydrolyzes |
gptkb:GTP
|
| gptkbp:locale |
gptkb:cytoplasm
axon mitotic spindle |
| gptkbp:molecularWeight |
~50 kDa
|
| gptkbp:mutationAssociatedWith |
neurological disorders
cortical malformations lissencephaly |
| gptkbp:PDB |
1TUB
|
| gptkbp:postTranslationalModification |
acetylation
detyrosination polyglutamylation polyglycylation tyrosination |
| gptkbp:presentIn |
cilia
flagella centrosome axoneme mitotic spindle |
| gptkbp:proteinFamily |
tubulin superfamily
|
| gptkbp:requires |
cell motility
chromosome segregation cell shape maintenance organelle movement |
| gptkbp:structure |
globular protein
|
| gptkbp:target |
gptkb:taxol
gptkb:vinblastine colchicine antimitotic drugs nocodazole |
| gptkbp:UniProtID |
P68363
|
| gptkbp:bfsParent |
gptkb:HDAC6
|
| gptkbp:bfsLayer |
7
|