|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:amendedBy
|
gptkb:alpha-tubulin
gptkb:cortactin
gptkb:Hsp90
histones
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:discoveredBy
|
Gregory D. Peterson et al.
|
|
gptkbp:domain
|
two catalytic domains
ubiquitin-binding zinc finger domain
|
|
gptkbp:encodedBy
|
gptkb:HDAC6_gene
|
|
gptkbp:enzymeClassification
|
gptkb:EC_3.5.1.98
|
|
gptkbp:fullName
|
gptkb:Histone_deacetylase_6
|
|
gptkbp:function
|
deacetylation of lysine residues on histone and non-histone proteins
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Hdac6
|
|
gptkbp:involvedIn
|
protein degradation
autophagy
cell motility
stress response
aggresome formation
|
|
gptkbp:locatedOnChromosome
|
Xq13.1
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
131 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:target
|
HDAC inhibitors
|
|
gptkbp:UniProtID
|
gptkb:Q9UBN7
|
|
gptkbp:bfsParent
|
gptkb:HDAC6
|
|
gptkbp:bfsLayer
|
7
|